« Back
Home /
Recombinant Rat IL-1 beta/IL1B Protein (mature form)

Recombinant Rat IL-1 beta/IL1B Protein (mature form)

Item no.	ELS-PKSR030425-100ug
Manufacturer	Elabscience
Amount	100 ug
Quantity options	100 ug 20 ug
Category	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines
Type	Proteins
Format	Lyophilized Powder
Applications	Cell Culture
Specific against	Rat (Rattus norvegicus)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 98 % as determined by reducing SDS-PAGE.
Sequence	Val 117-Ser 268
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL1F, catabolin, Il-1b, IL1-BETA, IL-1beta, IL1F2, Il1b, Interleukin-1 beta, IL-1 beta
Similar products	IL1B
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Cytokines
Manufacturer - Conjugate / Tag	None
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	17.4 kDa
Observed Molecular Weight	35 kDa
Background	Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).
Abbreviation	IL-1
Endotoxin	Please contact us for more information.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile 40mM Tris, 0.15 M NaCl, pH 7.8 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	1. Measured in a cell proliferation assay using D10.G4. 1 mouse helper T cells. The ED50 for this effect is typically 30-120 pg/mL. 2. Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The EC50 for this effect is typically 20-100ng/mL.
Protein Construction	A DNA sequence encoding the mature form of rat IL1B (Q63264-1) (Val 117-Ser 268) was expressed and purified.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSR030425-100ug-datasheet.pdf

ELS-PKSR030425-100ug-safety-datasheet.pdf