AKR7A2

Item no.	enz-485-20ug
Manufacturer	ProSpec
Amount	20 ug
Quantity options	1 mg 20 ug 5 ug
Category	Food Safety Mycotoxins Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 90.0% as determined by SDS-PAGE.
Sequence	MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELE M LSAASRVVSR AAVHCALRSP PPEARALAMS RPPPPRVASV LGTMEMGRRM DAPASAAAVR AFLERGHTEL DTAFMYSDGQ SETILGGLGL GLGGGDCRVK IATKANPWDG KSLKPDSVRS QLETSLKRLQ CPQVDLFYLH APDHGTPVEE TLHACQRLHQ EGKFVELGLS NYASWEVAEI CTLCKSNGWI L
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AKR7A2,Aflatoxin B1 aldehyde reductase member 2,AFAR,AFAR1,AFB1-AR1,AKR7,Succinic semialdehyde reductase,SSA reductase,AFB1 aldehyde reductase 1,Aldoketoreductase 7,AKR7A2
Available
Manufacturer - Category	ENZYMES
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human Aldo-Keto Reductase Family 7 Member A2
Formulation	The AKR7A2 solution contains 20mM Tris-HCl pH-8, 1mM DTT and 20% glycerol.
Introduction	AKR7A2 participates in the detoxification of aldehydes and ketones. AKR7A2 catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. AKR7A2 is involved in producing the neuromodulator gamma-hydroxybutyrate (GHB). AKR7A2 has extensive substrate specificity. AKR7A2 shows NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2 reduces 1, 2-naphthoquinone and 9, 10-phenanthrenequinone (in vitro). AKR7A2 reduces the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. AKR7A2 takes part in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile Filtered clear colorless solution.

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