FITC-Labeled Human FOLR1 Protein (FOL-HM4R1F)

FOLR1

Shipped with dry ice.

The protein has a predicted MW of 27.5 kDa. Due to glycosylation, the protein migrates to 37-47 kDa based on Bis-Tris PAGE result.

Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.

Supplied as 0.22 μm filtered solution in PBS (pH 7.4).