Comparison

Human GITR / TNFRSF18 Protein, Fc Tag European Partner

Item no. GIR-H5254-1mg
Manufacturer ACROBiosystems
Amount 200 ug x 5
Quantity options 100 ug 200 ug x 5
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, Fc
Purity 95%
Citations (1) Gurney A.L., et al., 1999, Curr. Biol. 9:215-218. (2) Park MS., et al., 2007, Yonsei Med J 48 (5): 839-46.
NCBI NP_004186.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias AITR,GITR,TNFRSF18,CD357
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag
C-Fc, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
41.0 kDa
Manufacturer - Format
Powder
Description
Human GITR, Fc Tag (GIR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Background
Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.
Molecule
GITR
Exp Region
Gln 26 - Glu 161
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.0 kDa. The protein migrates as 45-47 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
Tris with Glycine, Arginine and NaCl, pH 7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 200 ug x 5
Available: In stock
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