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Animal-Free GDF-11/BMP-11, Human (His)

Animal-Free GDF-11/BMP-11, Human (His)

Item no.	HY-P700020AF-10ug
Manufacturer	MedChem Express
Amount	10 ug
Quantity options	10 ug 1 ea 2 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	98.0
Sequence	MNLGLDCDEH SSESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGQCEY MFMQKYPHTH LVQQANPRGS AGPCCTPTKM SPINMLYFND KQQIIYGKIP GMVVDRCGCS
Citations	[1]Walker RG, et al. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017 Mar 3;15(1):19. [2]Schafer MJ, et al. The influence of GDF11 on brain fate and function. Geroscience. 2019 Feb;41(1):1-11. [3]Cox TC, et al. Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans. Hum Mutat. 2019 Oct;40(10):1813-1825. [4]Hannan NR, et al. BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. Cloning Stem Cells. 2009 Sep;11(3):427-35. [5]Pham HG, et al. BMP11 regulates thermogenesis in white and brown adipocytes. Cell Biochem Funct. 2021 Jun;39(4):496-510.
Smiles	MNLGLDCDEH SSESRCCRYP LTVDFEAFGW DWIIAPKRYK ANYCSGQCEY MFMQKYPHTH LVQQANPRGS AGPCCTPTKM SPINMLYFND KQQIIYGKIP GMVVDRCGCS
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Animal-Free GDF-11/BMP-11 Protein, Human (His),Human,E. coli
Shipping condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	Approximately 13.40 kDa
Product Description	Bone morphogenetic protein 11 (BMP-11; GDF11), also known as growth/differentiation factor 11, is a polymorphic ligand protein belonging to the TGFβ family. The GDF-11/BMP-11 signal activates the signal through activator receptor types I and II, resulting in the phosphorylation of SMAD2 and SMAD3[1]. GDF-11/BMP-11 is an important regulator of central nervous system (CNS) formation and fate[2]. Exogenous peripheral delivery of GDF-11/BMP-11 may enhance neurogenesis and angiogenesis and improve neuropathological outcomes in the elderly brain[2]. The total length of human GDF-11/BMP-11 protein is 407 amino acids (M1-M407), with a glycosylation domain. Animal-Free GDF-11/BMP-11 Protein, Human (His) has a total length of 109 amino acids (N299-S407), is expressed in E. coli with C-terminal His-tag.This product is for cell culture use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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