Product Description |
BMP-5 Protein, a vital TGF-beta superfamily member, is essential in cartilage and bone formation, as well as neurogenesis. It activates canonical BMP signaling through BMPR1A and BMPR2, phosphorylating SMAD1/5/8 for gene transcription modulation. BMP-5 engages non-canonical MAPK p38 signaling, promoting chondrogenic differentiation. Notably, it promotes HAMP expression, regulated by ERFE interaction, inhibiting BMP-induced HAMP transcription. The intricate signaling network highlights BMP-5's versatile regulatory functions in diverse cellular processes. Animal-Free BMP-5 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-5 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free BMP-5 Protein, Human (His) is 138 a.a., with molecular weight of ~16.57 kDa. |