Comparison

Animal-Free BMP-8b, Human (His) European Partner

Item no. HY-P700032AF-1ea
Manufacturer MedChem Express
Amount 1 ea
Quantity options 10 ug 1 ea 2 ug 50 ug
Category
Type Proteins Recombinant
Specific against other
Purity 98.0
Sequence AVRPLRRRQP KKSNELPQAN RLPGIFDDVH GSHGRQVCRR HELYVSFQDL GWLDWVIAPQ GYSAYYCEGE CSFPLDSCMN ATNHAILQSL VHLMMPDAVP KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH
Citations [1]Wu FJ, et al. Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway. Reproduction. 2020 Mar;159(3):315-324.|[2]Pellegrinelli V, et al. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974.|[3]Cheng Z, et al. BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer. Oncol Rep. 2014 Nov;32(5):1861-6.|[4]Yu YP, et al. BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma. Cancer Sci. 2020 May;111(5):1555-1566.|[5]Whittle AJ, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 2012 May 11;149(4):871-85.|[6]Ohinata Y, et al. A signaling principle for the specification of the germ cell lineage in mice. Cell. 2009 May 1;137(3):571-84.
Smiles AVRPLRRRQP KKSNELPQAN RLPGIFDDVH GSHGRQVCRR HELYVSFQDL GWLDWVIAPQ GYSAYYCEGE CSFPLDSCMN ATNHAILQSL VHLMMPDAVP KACCAPTKLS ATSVLYYDSS NNVILRKHRN MVVKACGCH
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Animal-Free BMP-8b Protein,Human (His),Human,E. coli
Shipping Condition Cool pack
Available
Manufacturer - Type
Recombinant Proteins
Shipping Temperature
Blue Ice
Storage Conditions
Stored at -20°C for 2 years
Molecular Weight
Approximately 16.48 kDa
Product Description
BMP-8 is a pleiotropic ligand protein act as a reproductive system regulator, enriched in the ovary. BMP-8 is encoded by a pair of genes BMP8A and BMP8B, belonging to TNF-β family[1]. BMP-8B is secreted by brown/beige adipocytes and enhances energy dissipation, serves as a potential targets in obesity[2]. BMP-8B also caspase-3 and -9 activation in pancreatic cancer cell, as well as decreasing mitochondrial membrane potential to induce apoptosis[3]. BMP-8b Protein, Human is 402 a.a. with 2 glycosylation domains. Animal-Free BMP-8a Protein, Human (His) is a animal free recombinant human protein produced in E. coli cells, with 139 a.a. (A264-H402) and N-terminal His-tag.This product is for cell culture use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 ea
Available: In stock
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