Item no. |
HY-P700052AF-1ea |
Manufacturer |
MedChem Express
|
Amount |
1 ea |
Quantity options |
10 ug
1 ea
2 ug
50 ug
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Purity |
98.00 |
Sequence |
QIGHPSPPPE KKELRKVAHL TGKSNSRSMP LEWEDTYGIV LLSGVKYKKG GLVINETGLY FVYSKVYFRG QSCNNLPLSH KVYMRNSKYP QDLVMMEGKM MSYCTTGQMW ARSSYLGAVF NLTSADHLYV NVSELSLVNF EESQTFFGLY KL |
Citations |
[1]Schneider P, et al. Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J Biol Chem. 1997 Jul 25;272(30):18827-33. [2]Liu W, et al. Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3. Structure. 2016 Nov 1;24(11):2016-2023. [3]Martínez-Lorenzo MJ, et al. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology. 1996 Dec;89(4):511-7. [4]Shudo K, et al. The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity. Eur J Immunol. 2001 Aug;31(8):2504-11. [5]Puppo F, et al. Fas, Fas ligand, and transfusion immunomodulation. Transfusion. 2001 Mar;41(3):416-8. [6]Ottonello L, et al. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes. J Immunol. 1999 Mar 15;162(6):3601-6. |
Smiles |
QIGHPSPPPE KKELRKVAHL TGKSNSRSMP LEWEDTYGIV LLSGVKYKKG GLVINETGLY FVYSKVYFRG QSCNNLPLSH KVYMRNSKYP QDLVMMEGKM MSYCTTGQMW ARSSYLGAVF NLTSADHLYV NVSELSLVNF EESQTFFGLY KL |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Animal-Free Fas Ligand Protein, Human (His),Human,E. coli |
Shipping condition |
Cool pack |
Available |
|
Manufacturer - Type |
Recombinant Proteins |
Shipping Temperature |
Blue Ice |
Storage Conditions |
Stored at -20°C for 2 years |
Molecular Weight |
Approximately 17.31 kDa |
Product Description |
Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS/CD95, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development[1]. Human Fas Ligand exhibits 4 isoforms, the soluble form (130-281 a.a.) of which plays an important role in the activation-induced cell death (AICD) of T lymphocytes Jurkat cells[3]. However the membrane-bound isoform could be responsible for its inflammatory activity[4]. Animal-Free Fas Ligand Protein, Human (His) has a total length of 152 amino acids (Q130-L281), is expressed in E. coli with N-terminal His-tag.This product is for cell culture use only. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.