Product Description |
LR3 IGF-I/IGF-1 protein, akin to insulin, exhibits potent growth-promoting activity, surpassing insulin's efficacy. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, even at markedly lower concentrations than insulin. Its multifaceted roles extend to potential involvement in synapse maturation and Ca(2+)-dependent exocytosis crucial for olfactory bulb sensory perception. As a ligand for IGF1R, LR3 IGF-I triggers tyrosine kinase activity, activating PI3K-AKT/PKB and Ras-MAPK pathways. Forming ternary complexes with integrins and IGFR1, LR3 IGF-I influences comprehensive IGF1 signaling and engages in diverse molecular interactions, including with SH2D3C isoform 2. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IGF-I/IGF-1 Protein, Human (His) is 70 a.a., with molecular weight of ~8.59 kDa. |