Product Description |
IL-1 alpha protein, located intracellularly, is a key cytokine linking innate and adaptive immunity. Upon binding to IL1R1 with IL1RAP, it forms a high-affinity receptor complex, initiating signaling cascades with adapter molecules like MYD88, IRAK1, or IRAK4, activating NF-kappa-B and MAPK pathways. Intracellularly, IL-1 alpha acts as an alarmin, released upon cell death to induce inflammation. It senses DNA damage and interacts with proteins, including TMED10, IL1R1, and S100A13, regulating translocation, secretion, and export processes. Animal-Free IL-1 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-1 alpha protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-1 alpha Protein, Human (His) is 159 a.a., with molecular weight of ~18.99 kDa. |