Product Description |
IL-34 Protein, a crucial cytokine, fosters monocyte and macrophage proliferation, survival, and differentiation. It plays a pivotal role in innate immunity and inflammation by promoting pro-inflammatory chemokine release. IL-34 critically regulates osteoclast proliferation, impacting bone resorption. Signaling via CSF1R and downstream effectors, IL-34 stimulates MAPK1/ERK2 and MAPK3/ERK1 phosphorylation. Existing as a homodimer, it specifically interacts with CSF1R, contributing to its intricate regulatory network. Animal-Free IL-34 Protein, Human (His) is the recombinant human-derived animal-FreeIL-34 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-34 Protein, Human (His) is 222 a.a., with molecular weight of ~26.17 kDa. |