BMP-4 Protein, Human (His) European Partner

Manufacturer MedChem Express
Type Proteins Recombinant
Specific against other
Amount 2ug
Item no. HY-P7007A-2ug
eClass 6.1 34160400
eClass 9.0 42020190
Product Description
Bone morphogenetic protein 4 (BMP-4) is a polymorphic ligand protein belonging to the TGF-β family, which is involved in the circulation of the vascular system and can activate receptors on vascular cells. BMP-4 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to increase plaque formation and promote oxidative stress, endothelial dysfunction, and osteogenic differentiation through its pro-inflammatory and pro-atherogenic effects. BMP-4 Protein, Human (His) has a total length of 116 amino acids (S293-R408), is expressed in E. coli cells with N-terminal 6*His-tag.
Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Gene ID: 652 | Accession: P12644 (S293-R408)
[1].Yang P, et al. The role of bone morphogenetic protein signaling in vascular calcification. Bone. 2020 Dec; 141:115542. | [2].Miyazawa K, et al. Regulation of TGF-β Family Signaling by Inhibitory Smads. Cold Spring Harb Perspect Biol. 2017 Mar 1; 9(3):a022095. | [3].Herrera B, et al. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009 Mar 19; 10:20. | [4].Yang X, et al. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ Res. 2005 May 27; 96(10):1053-63. | [5].Scimeca M, et al. Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors. Nutr Metab Cardiovasc Dis. 2019 Dec; 29(12):1330-1336. | [6].David L, et al. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 2009 Jun; 20(3):203-12. | [7].Dhore CR, et al. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2001 Dec; 21(12):1998-2003. | [8].Demer LL, et al. Mechanism of calcification in atherosclerosis. Trends Cardiovasc Med. 1994 Jan-Feb; 4(1):45-9. | [9].Boström K, et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993 Apr; 91(4):1800-9. | [10].Xu RH, et al. BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol. 2002 Dec; 20(12):1261-4. | [11].Hatakeyama Y, et al. Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis. J Cell Biochem. 2004 Apr 15; 91(6):1204-17.
Approximately 18 kDa

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 2ug
Available: In stock

Delivery expected until 4/13/2023 


Add to wishlist

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?