Product Description |
alpha-Synuclein (SNCA), a key neuronal protein, regulates synaptic activity, including vesicle trafficking and neurotransmitter release. As a monomer, it enhances vesicle exocytosis, promoting fusion and dilation of fusion pores and increasing local Ca(2+) release. In its multimeric membrane-bound state, SNCA acts as a chaperone, aiding SNARE folding, crucial for normal assembly during aging. SNCA also modulates dopamine neurotransmission through interaction with DAT1. Existing as both a monomer and homotetramer, SNCA's dynamic balance is crucial for homeostasis. Interactions with UCHL1, synphilin-1/SNCAIP, CALM1, STXBP1, VAMP2, SNAP25, RPH3A, RAB3A, SERF1A, and SEPTIN4 underscore its role in intricate molecular networks governing synaptic function. SNCA Protein, Human (His) is the recombinant human-derived SNCA protein, expressed by E. coli, with N-6*His labeled tag. The total length of SNCA Protein, Human (His) is 140 a.a., with molecular weight of ~18.0 kDa. |