Product Description |
The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2', 3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His-SUMO) is the recombinant human-derived cGAS protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of cGAS Protein, Human (His-SUMO) is 362 a.a., with molecular weight of ~58.3 kDa. |