Product Description |
IRF3 Protein, a vital transcriptional regulator, orchestrates type I interferon-dependent immune responses against DNA and RNA viruses. In uninfected cells, it remains inactive, but viral infection triggers phosphorylation by IKBKE and TBK1 kinases, leading to conformational changes. This activates transcription of type I IFN and IFN-stimulated genes, with IRF3 transitioning from monomer to dimer form for DNA binding and nuclear localization. The cascade involves innate adapter proteins (MAVS, STING1, or TICAM1), culminating in IRF3 activation and IFN induction. IRF3 Protein, Mouse (P.pastoris, Myc, His) is the recombinant mouse-derived IRF3 protein, expressed by P. pastoris, with C-Myc, N-10*His labeled tag. The total length of IRF3 Protein, Mouse (P.pastoris, Myc, His) is 419 a.a., with molecular weight of ~50.9 kDa. |