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BMP-15, Human (His, Myc, soluition)

BMP-15, Human (His, Myc, soluition)

Item no.	HY-P72426A-1ea
Manufacturer	MedChem Express
Amount	1 ea
Quantity options	1 ea 20 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	97.00
Dry ice	Yes
Sequence	QADGISAEVT ASSSKHSGPE NNQCSLHPFQ ISFRQLGWDH WIIAPPFYTP NYCKGTCLRV LRDGLNSPNH AIIQNLINQL VDQSVPRPSC VPYKYVPISV LMIEANGSIL YKEYEGMIAE SCTCR
Citations	[1]Galloway SM, et al. Bmp15 mutations and ovarian function. Mol Cell Endocrinol. 2002 May 31;191(1):15-8. [2]Liu MN, et al. The role of BMP15 and GDF9 in the pathogenesis of primary ovarian insufficiency. Hum Fertil (Camb). 2021 Dec;24(5):325-332. [3]Zhao Z, et al. BMP15 regulates AMH expression via the p38 MAPK pathway in granulosa cells from goat. Theriogenology. 2018 Sep 15;118:72-79. [4]Cao LY, et al. Aberrant BMP15/HIF-1α/SCF signaling pathway in human granulosa cells is involved in the PCOS related abnormal follicular development. Gynecol Endocrinol. 2022 Sep 23:1-7. [5]Shimizu K, et al. Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells. J Assist Reprod Genet. 2019 Jun;36(6):1185-1194.
Smiles	QADGISAEVT ASSSKHSGPE NNQCSLHPFQ ISFRQLGWDH WIIAPPFYTP NYCKGTCLRV LRDGLNSPNH AIIQNLINQL VDQSVPRPSC VPYKYVPISV LMIEANGSIL YKEYEGMIAE SCTCR
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	BMP-15 Protein, Human (His, Myc, soluition),Human,E. coli
Shipping condition	Dry ice
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Dry Ice
Storage Conditions	Stored at -80°C for 1 year
Molecular Weight	Approximately 23.0 kDa
Product Description	Bone morphogenetic protein 15 (BMP-15; GDF9B), also known as growth differentiation factor 9B (GDF9B), is a polymorphic ligand protein of the TGFβ family and is only expressed in follicular cells. BMP15 is closely related to GDF9 and synergistically regulates the genetic development of follicles. BMP15 is involved in p38 MAPK and HIF-1α/SCF signaling pathway, respectively, and can up-regulate the expression of anti-Mullerian hormone (AMH) and polycystic ovarian syndrome (PCOS) related stem cell factor (SCF) in granulosa cells. The total length of human BMP-15 protein is 392 amino acids (M1-R392), with 4 glycosylation domains. BMP-15 Protein, Human (His, Myc, soluition) is the protein in solution form, expressed in E. coli cells with a N-terminal His-tag and a C-terminal Myc-tag, respectively.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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