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IFN-gamma R1/CD119, Mouse (HEK293, His)

IFN-gamma R1/CD119, Mouse (HEK293, His)

Item no.	HY-P72611-50ug
Manufacturer	MedChem Express
Amount	50 ug
Quantity options	100 mg 100 ug 10 ug 1 ea 1 mg 2 ug 500 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	98.0
Sequence	ALTSTEDPEP PSVPVPTNVL IKSYNLNPVV CWEYQNMSQT PIFTVQVKVY SGSWTDSCTN ISDHCCNIYE QIMYPDVSAW ARVKAKVGQK ESDYARSKEF LMCLKGKVGP PGLEIRRKKE EQLSVLVFHP EVVVNGESQG TMFGDGSTCY TFDYTVYVEH NRSGEILHTK HTVEKEECNE TLCELNISVS TLDSRYCISV DGISSFWQVR TEKSKDVCIP PFHDDRKD
Citations	[1]Castro F, et al. Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion. Front Immunol. 2018 May 4;9:847. [2]van de Vosse E, et al. IFN-γR1 defects: Mutation update and description of the IFNGR1 variation database. Hum Mutat. 2017 Oct;38(10):1286-1296. [3]Ding H, et al. Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway. Biomed Pharmacother. 2022 Nov;155:113683. [4]Goto Y, et al. Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation. Biochim Biophys Acta Mol Cell Res. 2018 Jun;1865(6):874-888.
Smiles	ALTSTEDPEP PSVPVPTNVL IKSYNLNPVV CWEYQNMSQT PIFTVQVKVY SGSWTDSCTN ISDHCCNIYE QIMYPDVSAW ARVKAKVGQK ESDYARSKEF LMCLKGKVGP PGLEIRRKKE EQLSVLVFHP EVVVNGESQG TMFGDGSTCY TFDYTVYVEH NRSGEILHTK HTVEKEECNE TLCELNISVS TLDSRYCISV DGISSFWQVR TEKSKDVCIP PFHDDRKD
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IFN-gamma R1/CD119 Protein, Mouse (HEK293, His),Mouse,HEK293
Shipping condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	33-57 kDa
Product Description	IFN-gamma R1 (CD119), one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R1 forms the functional receptor with IFN-gamma R2. Upon binding with IFN-gamma, IFN-gamma R1 and IFN-gamma R2 oligomerize and transphosphorylate[1]. Then, JAK1 and JAK2 are phosphorylated and activated, and STAT1 is recruited to the receptor complex. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54)[2]. IFN-gamma R1/CD119 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R1 with C-terminal 6*His tag, which is produced in HEK293 cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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