Product Description |
TRAIL/TNFSF10 protein, a cytokine, binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG. It induces apoptosis, a process that may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG, which lack the ability to induce apoptosis. Existing as a homotrimer, one TNFSF10 homotrimer interacts with three TNFSF10A monomers, and similarly, one TNFSF10 homotrimer interacts with three TNFSF10B monomers. This intricate interaction underlines the complexity of TRAIL/TNFSF10-mediated apoptotic signaling, showcasing its ability to engage multiple receptors and form distinct molecular configurations for its biological activity. TRAIL/TNFSF10 Protein, Human (N-His) is the recombinant human-derived TRAIL/TNFSF10 protein, expressed by E. coli, with N-6*His labeled tag. The total length of TRAIL/TNFSF10 Protein, Human (N-His) is 168 a.a., with molecular weight of ~22 kDa. |