Product Description |
YES1, a non-receptor protein tyrosine kinase, regulates cell processes like growth, survival, apoptosis, and cell-cell adhesion. Activated by RTKs (EGFR, PDGFR, CSF1R, FGFR), it phosphorylates downstream substrates. YES1 facilitates EGFR-induced tight junction assembly and phosphorylates CTNND1 at cell-cell contacts. CXCL12 stimulation triggers YES1-mediated T-cell migration. In CD95L/FASLG signaling, YES1 mediates AKT-dependent cell migration. YES1 phosphorylates CDK4 for G1 regulation, influences G2/M progression, cytokinesis, and enhances the transport activity of OCT2. YES1 Protein, Human (sf9, His-GST) is the recombinant human-derived YES1 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of YES1 Protein, Human (sf9, His-GST) is 542 a.a., with molecular weight of ~75 kDa. |