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IL-12R beta 2, Mouse (HEK293, His)

IL-12R beta 2, Mouse (HEK293, His)

Item no.	HY-P74834-10ug
Manufacturer	MedChem Express
Amount	10 ug
Quantity options	100 ug 10 ug 2 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	95.00
Sequence	NIDVCKLGTV TVQPAPVIPL GSAANISCSL NPKQGCSHYP SSNELILLKF VNDVLVENLH GKKVHDHTGH SSTFQVTNLS LGMTLFVCKL NCSNSQKKPP VPVCGVEISV GVAPEPPQNI SCVQEGENGT VACSWNSGKV TYLKTNYTLQ LSGPNNLTCQ KQCFSDNRQN CNRLDLGINL SPDLAESRFI VRVTAINDLG NSSSLPHTFT FLDIVIPLPP WDIRINFLNA SG
Citations	[1]Esther van de Vosse, et al. IL-12Rβ1 deficiency: mutation update and description of the IL12RB1 variation database. Hum Mutat. 2013 Oct;34(10):1329-39. [2]Ryuta Nishikomori, et al. Activated STAT4 has an essential role in Th1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol. 2002 Oct 15;169(8):4388-98. [3]Xuefang Cao, et al. Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance. Cancer Res. 2009 Nov 15;69(22):8700-9. [4]Gaëlle Chognard, et al. The dichotomous pattern of IL-12r and IL-23R expression elucidates the role of IL-12 and IL-23 in inflammation. PLoS One. 2014 Feb 21;9(2):e89092.
Smiles	NIDVCKLGTV TVQPAPVIPL GSAANISCSL NPKQGCSHYP SSNELILLKF VNDVLVENLH GKKVHDHTGH SSTFQVTNLS LGMTLFVCKL NCSNSQKKPP VPVCGVEISV GVAPEPPQNI SCVQEGENGT VACSWNSGKV TYLKTNYTLQ LSGPNNLTCQ KQCFSDNRQN CNRLDLGINL SPDLAESRFI VRVTAINDLG NSSSLPHTFT FLDIVIPLPP WDIRINFLNA SGSRGTLQWE DEGQVVLNQL RYQPLNSTSW NMVNATNAKG KYDLRDLRPF TEYEFQISSK LHLSGGSWSN WSESLRTRTP EEEPVGILDI WYMKQDIDYD RQQISLFWKS LNPSEARGKI LHYQVTLQEV TKKTTLQNTT RHTSWTRVIP RTGAWTASVS AANSKGASAP THINIVDLCG TGLLAPHQVS AKSENMDNIL VTWQPPKKAD SAVREYIVEW RALQPGSITK FPPHWLRIPP DNMSALISEN IKPYICYEIR VHALSESQGG CSSIRGDSKH KAPVSGPHIT AITEKKERLF ISWTHIPFPE QRGCILHYRI YWKERDSTAQ PELCEIQYRR SQNSHPISSL QPRVTYVLWM TAVTAAGESP QGNEREFCPQ GKAN
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-12R beta 2 Protein, Mouse (HEK293, His),Mouse,HEK293
Shipping condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	100-130 kDa
Product Description	IL-12R beta 2 protein is an IL-12 cytokine surface receptor that activates the Jak-Stat signaling cascade pathway and is involved in IL-12-mediated immune regulation. IL-12R beta 2 Protein, Mouse (HEK293, His) is expressed by HEK 293 cells with a transmembrane region (W638-I658) and a His tag at the C-terminus[1].

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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