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IFNAR1, Rhesus Macaque (HEK293)

IFNAR1, Rhesus Macaque (HEK293)

Item no.	HY-P76406-100ug
Manufacturer	MedChem Express
Amount	100 ug
Quantity options	100 ug 10 ug 1 ea 2 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	96.00
Sequence	AGGKNLKSPQ KVEVDVIDDN FILRWNRSEE SVGNVTFSFD YQKPEMDNWI KLPGCQNMTS TKCNFSSLKL NIYDEIKLRI RAEKENTSSW CEVDSFTPFR KAQIGPPEVH LEAEDKAIVI YISPPGTEDS VMWALDRSSF TYSLVIWKNS SSVEERIENI YSRHKISKLS PETTYCLKVK AALLTSRKIG VYGPVHCIKT TVENELPPPE NIEVIVQNQN YVLKWDYTYA NM
Citations	[1]Zanin N, et al. Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol. 2021 Jan 20;11:615603.\|[2]Shemesh M, et al. IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal. 2021 Nov 23;14(710):eabe4627.\|[3]Jun Zou, et al. Chapter 7 - Antiviral Immunity: Origin and Evolution in Vertebrates. The Evolution of the Immune System. 2016,Pages 173-204.\|[4]Pogue SL, et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004 Feb;24(2):131-9.
Smiles	AGGKNLKSPQ KVEVDVIDDN FILRWNRSEE SVGNVTFSFD YQKPEMDNWI KLPGCQNMTS TKCNFSSLKL NIYDEIKLRI RAEKENTSSW CEVDSFTPFR KAQIGPPEVH LEAEDKAIVI YISPPGTEDS VMWALDRSSF TYSLVIWKNS SSVEERIENI YSRHKISKLS PETTYCLKVK AALLTSRKIG VYGPVHCIKT TVENELPPPE NIEVIVQNQN YVLKWDYTYA NMTFQVQWLH AFLKRKPGNH LYKWKQIPDC KNVTTTQCVF PQNTFQKGIY LLRVQASDGN NTSFWSEEIK FDTEIQASLL PPVFNIRSLS DSLHISIGAP KWSENKPVIQ DYPLIYEILF WENTSKAERK IIKKKTDVTI PNLKPLTVYC VKARAHSMDE KLNKSSVFSD VVCEETKSGN TSK
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IFNAR1 Protein,Rhesus Macaque (HEK293),Rhesus Macaque,HEK293
Shipping Condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	Approximately 68-100 kDa due to the glycosylation.
Product Description	IFNAR1, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Rhesus Macaque (HEK293) is a recombinant rhesus macaque IFNAR1 (M1-K437) without any tag, which is produced in HEK293 cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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