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GDF-15, Mouse (Biotinylated, HEK293, Fc)

GDF-15, Mouse (Biotinylated, HEK293, Fc)

Item no.	HY-P77946-100ug
Manufacturer	MedChem Express
Amount	100 ug
Quantity options	100 ug 20 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Purity	95.0
Sequence	SAHAHPRDSC PLGPGRCCHL ETVQATLEDL GWSDWVLSPR QLQLSMCVGE CPHLYRSANT HAQIKARLHG LQPDKVPAPC CVPSSYTPVV LMHRTDSGVS LQTYDDLVAR GCHCA
Citations	[1]Assadi A, et al. GDF15, an update of the physiological and pathological roles it plays: a review. Pflugers Arch. 2020 Nov;472(11):1535-1546. [2]Breen DM, et al. GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates. Cell Metab. 2020 Dec 1;32(6):938-950.e6.
Smiles	SAHAHPRDSC PLGPGRCCHL ETVQATLEDL GWSDWVLSPR QLQLSMCVGE CPHLYRSANT HAQIKARLHG LQPDKVPAPC CVPSSYTPVV LMHRTDSGVS LQTYDDLVAR GCHCA
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc),Mouse,HEK293
Shipping condition	Cool pack
Available
Manufacturer - Type	Recombinant Proteins
Shipping Temperature	Blue Ice
Storage Conditions	Stored at -20°C for 2 years
Molecular Weight	40-50 kDa
Product Description	Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor β (TGF-β) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-β (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCγ)[1]. GDF-15 Protein, Mouse (Biotinylated, HEK293, Fc) has 115 amino acids expressed by HEK293 cells with N-terminal hFc tag.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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