Comparison

ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) European Partner

Manufacturer MedChem Express
Category
Type Proteins Recombinant
Specific against other
Amount 20 ug
Item no. HY-P78056-20ug
eClass 6.1 34160400
eClass 9.0 42020190
Available
Product Description
ALCAM/CD166 protein serves as a pivotal cell adhesion molecule, orchestrating a spectrum of cellular interactions. It mediates both heterotypic cell-cell contacts through its interaction with CD6 and homotypic cell-cell contacts, promoting T-cell activation and proliferation. ALCAM contributes significantly to the formation and maturation of the immunological synapse by engaging with CD6. Additionally, it facilitates homotypic interactions with cells expressing ALCAM. Acting as a ligand for the LILRB4 receptor, ALCAM enhances LILRB4-mediated inhibition of T cell proliferation. The protein is indispensable for normal hematopoietic stem cell engraftment in the bone marrow and mediates the attachment of dendritic cells onto endothelial cells through homotypic interactions. ALCAM plays a vital role in inhibiting endothelial cell migration while promoting endothelial tube formation. It is crucial for the organization of the lymph vessel network and hematopoiesis, ensuring normal numbers of hematopoietic stem cells in the bone marrow. ALCAM's diverse functions extend to promoting in vitro osteoblast proliferation and differentiation, as well as influencing neurite extension, axon growth, and axon guidance. Notably, it inhibits membrane-bound isoforms by competing for the same interaction partners, restricts cell attachment via homotypic interactions, and simultaneously promotes endothelial cell migration while inhibiting endothelial cell tube formation. ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived ALCAM/CD166 protein, expressed by HEK293 , with C-His labeled tag. The total length of ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) is 499 a.a., with molecular weight of 70-80 kDa.
StorageTemperature
Stored at -20°C for 2 years
Shipping
Blue Ice
Molecular Weight
70-80 kDa
Manufacturers Product type
Recombinant Proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
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