Product Description |
IL-4 protein, mainly secreted by mast cells, T-cells, eosinophils, and basophils, crucially regulates antibody production, hematopoiesis, and immune responses. It induces class II MHC expression on B-cells, enhances IgE and IgG1 secretion, and regulates CD23 and IL31RA expression. Additionally, IL-4 stimulates dendritic cell autophagy, impacting mTORC1 signaling and RUFY4 induction. Beyond immunological functions, IL-4 influences brain functions like memory and learning. Binding to IL-4R activates JAK3 and JAK1, initiating STAT6 activation. IL-4's diverse effects are mediated through interactions with IL-4R and IL13RA1. IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-4 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) is 129 a.a., with molecular weight of 23-25 kDa. |