Product Description |
NKG2D/CD314 Protein functions as a pivotal activating and costimulatory receptor in immunosurveillance, binding diverse stress-inducible ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T-cell activation in CD8(+) T-cell-mediated adaptive responses. The receptor facilitates perforin-mediated elimination of ligand-expressing tumor cells, triggers calcium influx leading to TNF-alpha expression, and participates in NK cell-mediated bone marrow graft rejection. Its ligand-binding capacity extends to various MHC class I-related glycoproteins. NKG2D/CD314 forms homodimers and heterohexamers, crucial for NK cell function, and establishes disulfide-bonded heterodimers with CD94, interacting with CEACAM1 and recruiting PTPN6 for VAV1 dephosphorylation. NKG2D/CD314 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of NKG2D/CD314 Protein, Human (Biotinylated, HEK293, His-Avi) is 139 a.a., with molecular weight of ~19.0 kDa. |