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Human IL-15 Protein (E. coli), premium grade European Partner

Item no. IL5-H4117-20ug
Manufacturer ACROBiosystems
Amount 20 ug
Quantity options 500 ug x 2 20 ug 50 ug
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag Unconjugated
Purity 95%
Citations (1) Grabstein KH, et al. 1994, Science 264 (5161): 965-8. (2) Malamut G, et al. 2010, J. Clin. Invest. 120 (6): 2131-43. (3) Klebanoff CA, et al. 2004, Proc. Natl. Acad. Sci. U.S.A. 101 (7): 1969-74. (4) Teague RM, et al. 2006, Nat. Med. 12 (3): 335-41.
NCBI AAH18149.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias IL-15,Interleukin-15,MGC9721
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / Cytokines&Growth Factors
Manufacturer - Conjugate / Tag
Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
12.9 kDa
Manufacturer - Format
Powder
Description
Human IL-15, premium grade (IL5-H4117) is expressed from E.coli cells. It contains AA Asn 49 - Ser 162 (Accession # P40933-1).
Background
Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
Molecule
IL-15
Exp Region
Asn 49 - Ser 162
Characteristics
This protein carries no "tag". The protein has a calculated MW of 12.9 kDa. The protein migrates as 13 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin
0.01 EU per μg
Buffer
25 mM Histidine, pH6.2
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
available

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