Comparison

Human IL-6 Protein, premium grade European Partner

Item no. IL6-H4218-20ug
Manufacturer ACROBiosystems
Amount 20 ug
Quantity options 100 ug x 10 20 ug 50 ug
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated
Purity 95%
Citations (1) Ferguson-Smith AC,et.al. 1988, Genomics 2 (3): 203-8. (2) Schwantner A,et. al. 2004, J. Biol. Chem. 279 (1): 571-6. (3) Schuster B,et. al. 2003, J. Biol. Chem. 278 (11): 9528-35. (4) Taga T,et al.1989, Cell 58 (3): 573-81.
NCBI NP_000591
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias IL6,Interleukin-6,BSF2,HSF,IFNB2
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / ActiveMax® Cytokines
Manufacturer - Conjugate / Tag
Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
20.8 kDa
Manufacturer - Format
Powder
Description
Human IL-6, premium grade (IL6-H4218) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Met 212 (Accession # NP_000591.1).
Background
Interleukin 6 (IL-6) is also known as HGF, BSF2, HSF, IFNB2 and IL-6, originally identified as a B cell differentiation factor, is a multifunctional cytokine that regulates immune responses, hematopoiesis, acute phase responses, and inflammatory reactions.It is secreted by T cells, macrophages , monocytes, fibroblasts, endothelial cells, et.al. to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. IL-6 is relevant to many disease processes such as diabetes, atherosclerosis, depression, Alzheimer's Disease, systemic, lupus erythematosus, prostate cancer and rheumatoid arthritis. Advanced/metastatic cancer patients have higher levels of IL-6 in their blood.Hence there is an interest in developing anti-IL-6 agents as therapy against many of these diseases.
Molecule
IL-6
Exp Region
Val 30 - Met 212
Characteristics
This protein carries no "tag". The protein has a calculated MW of 20.8 kDa. The protein migrates as 23-29 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.01 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
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