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Human IL-3 R alpha / CD123 Protein, Llama IgG2b Fc Tag, low endotoxin European Partner

Item no. ILA-H5255-1mg
Manufacturer ACROBiosystems
Amount 500 ug x 2
Quantity options 100 ug 500 ug x 2
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated
Purity 90%
Citations (1) Mardiros A., et al. 2013, Blood., 122(18), 3138-48. (2) Rapoport AP., et al. 1996, Blood., 87(1), 112-22. (3) Klöß S., et al. 1996, Hum Gene Ther., 28(10), 897-913.
NCBI NP_002174.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
C-LlamaFc(LlamaIgG2b), Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
60.9 kDa
Manufacturer - Format
Powder
Description
Human IL-3 R alpha Protein, Llama IgG2b Fc Tag (ILA-H5255) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305  (Accession # P26951-1).
Background
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells.
Molecule
IL-3 R alpha
Exp Region
Thr 19 - Arg 305
Characteristics
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 60.9 kDa. The protein migrates as 45 kDa, 55 kDa and 80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
0.01 EU per μg
Buffer
Tris with Glycine,  Arginine and NaCl,  pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ug x 2
Available: In stock
available

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