Comparison

Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified) European Partner

Item no. IT7-H52W4-100ug
Manufacturer ACROBiosystems
Amount 100 ug
Quantity options 100 ug 500 ug x 2
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, HIS
Purity 90%
Citations (1) Arthos Jet, et al., 2008, Nat Immunol., 9(3), 301-9. (2) Monteiro P, et al., 2011, J Immunol.l., 186(8), 4618-30. (3) Chen YB, et al., 2013, Bone Marrow Transplant., 48(4), 598-603.
NCBI NP 000876.3 (ITGA4) , NP_000880.1 (ITGB7)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Integrin alpha 4 beta 7,ITGA4&ITGB7
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
C-10xHis | Native, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
111.4 kDa (ITGA4) & 83.7 kDa (ITGB7)
Manufacturer - Format
Powder
Description
Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) & P26010-1 (ITGB7)).
Background
Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
Molecule
Integrin alpha 4 beta 7
Exp Region
Tyr 34 - Thr 977 (ITGA4) & Glu 20 - His 723 (ITGB7)
Characteristics
Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) & 83.7 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB7 contains no tag but a basic tail at the C-terminus. The protein migrates as 130-150 kDa (ITGA4) and 65 kDa, 70 kDa, 100-120 kDa (ITGB7) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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