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Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin

Human LIGHT / TNFSF14 Protein, Mouse IgG2a Fc Tag, low endotoxin

Item no.	LIT-H5256-1mg
Manufacturer	ACROBiosystems
Amount	500 ug x 2
Quantity options	100 ug 500 ug x 2
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Human (Homo sapiens)
Host	HEK293
Isotype	IgG2a
Conjugate/Tag	Unconjugated, N-mFc
Purity	95%
Citations	(1) Mauri DN., et al. 1998, Immunity., 8(1), 21-30. (2) Granger SW., et al. 2003, Cytokine Growth Factor Rev., 14(3-4), 289-96. (3) Pasero C., et al. 2009, Curr Mol Med., 9(7), 911-27.
NCBI	NP 003798.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD258 antigen,CD258,HVEM-L,LIGHT,LTg,TNFSF14,TR2,HVEML
Shipping Condition	Room temperature
Available
Manufacturer - Category	Protein / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag	N-mFc(mIgG2a), Unconjugated
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	45.1 kDa
Manufacturer - Format	Powder
Description	Human LIGHT Protein, Mouse IgG2a Fc Tag (LIT-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1).
Background	Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.
Molecule	LIGHT
Exp Region	Asp 74 - Val 240
Characteristics	This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 45.1 kDa. The protein migrates as 50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	0.1 EU per μg
Buffer	Tris with Glycine, Arginine and NaCl, pH 7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

LIT-H5256-1mg-datasheet.pdf

LIT-H5256-1mg-safety-datasheet.pdf