Comparison

Human Mucin-1 / MUC-1 Protein, Fc Tag European Partner

Item no. MU1-H5252-1mg
Manufacturer ACROBiosystems
Amount 500 ug x 2
Quantity options 100 ug 500 ug x 2
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, Fc
Purity 95%
Citations (1) Gendler SJ., et al., 1990, J. Biol. Chem. 265 (25): 15286-93. (2) Hollingsworth MA., et al., 2004, Nat. Rev. Cancer 4 (1): 45-60. (3) Moncada DM., et al., 2003, Trends Parasitol 19 (7): 305-311. (4) Singh PK., et al., 2006, Trends Cell Biol 16 (9): 467-476. (5) Linden SK., et al., 2009, PLoS Pathog. 5 (10): e1000617.
NCBI AAI20976
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1/SEC,MUC-1/X,MUC1/ZD,PEM,PEMT,PUM,CA 15-3,Episialin
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
C-Fc, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
40.76 kDa
Manufacturer - Format
Powder
Description
Human Mucin-1, Fc Tag (MU1-H5252) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Gly 167 (Accession # P15941-11).
Background
Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
Molecule
Mucin-1
Exp Region
Ser 33 - Gly 167
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.76 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
50 mM Tris, 100 mM Glycine, pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ug x 2
Available: In stock
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