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Human NKG2C&CD94 Protein, Fc Tag European Partner

Item no. NC4-H5258-100ug
Manufacturer ACROBiosystems
Amount 100 ug
Quantity options 100 ug 500 ug x 2
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, Fc
Purity 95%
Citations (1) Petrie EJ. J Exp Med. 2008. 205(3):725-35. (2) Kaiser BK. Proc Natl Acad Sci U S A. 2008. 105(18):6696-701. (3) Sun C, et al. Oncoimmunology. 2016. 6(1):e1264562.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias NKG2C & CD94
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein
Manufacturer - Conjugate / Tag
C-Fc, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
57.1 kDa
Manufacturer - Format
Powder
Description
Human NKG2C&CD94, Fc Tag (NC4-H5258) is expressed from human 293 cells (HEK293). It contains AA Ile 94 - Leu 231 (NKG2C) & Asp 57 - Ile 179 (CD94) (Accession # P26717-1 (NKG2C) & Q13241-1 (CD94) (F102S, mutation caused by sequence update)).
Background
CD94 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. NKG2C/CD159c is used as a receptor for NK cells and some cytotoxic T cells to recognize MHC class I HLA-E molecules. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.
Molecule
NKG2C & CD94
Exp Region
Ile 94 - Leu 231 (NKG2C) & Asp 57 - Ile 179 (CD94)
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 57.1 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state
● -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

Delivery expected until 2/19/2026 

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