Recombinant human PEA-15 protein

Human

Phospho-enriched protein in astrocytes 15 kDa (PEA-15) is a death effector domain (DED) -containing protein predominantly expressed in the central nervous system, particularly in astrocytes. This protein has been implicated in the regulation of multiple cellular processes including apoptosis, proliferation, glucose transport, adhesion and migration. Increased PEA-15 levels may affect tumorigenesis and cancer progression, thus it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. Recombinant human PEA-15 was expressed in E. coli and purified by using conventional chromatography.

Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% glycerol

Beguinot F., et al. (2009) Am J Physiol Endocrinol Metab. 297(3):E592-601.; ; ueno NT., et al. (2008) Cancer Res. 68(22):9302-10.; ;

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.