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Recombinant human Enolase 1/ENO1 protein

Recombinant human Enolase 1/ENO1 protein

Item no.	NKM-ATGP0404-100ug
Manufacturer	NKMAX
Amount	100 ug
Quantity options	100 ug 20 ug 500 ug
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Testicular & Prostate Cancer Stem Cell Markers
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Untagged
Purity	> 95% by SDS-PAGE
Sequence	MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IG
Citations	Das R., et al. (2009) Blood. 113(22):5371-2. ueno NT., et al. (2008) Cancer Res. 68(22):9302-10. Chen X, et al. Interaction between granulin A and enolase 1 attenuates the migration and invasion of human hepatoma cells. (Oncotarget. 2017){https://pubmed.ncbi.nlm.nih.gov/28415822/} Hashimoto Y, et al. Comparison of clinical characteristics in patients with Vogt-Koyanagi-Harada disease with and without anti-retinal antibodies. (Graefes Arch Clin Exp Ophthalmol. 2019){https://pubmed.ncbi.nlm.nih.gov/31065846/} Hirakata T, et al. Acute unilateral inner retinal dysfunction with photophobia: importance of electrodiagnosis. (Jpn J Ophthalmol. 2020){https://pubmed.ncbi.nlm.nih.gov/33180210/} Hashimoto Y, et al. Comparison of clinical characteristics in patients with acute zonal occult outer retinopathy according to anti-retinal antibody status. (Graefes Arch Clin Exp Ophthalmol. 2021){https://pubmed.ncbi.nlm.nih.gov/33876277/} Inoue Y, et al. α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation. (Cell Mol Life Sci. 2022){https://pubmed.ncbi.nlm.nih.gov/35916996/}
NCBI	NP_001419.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Alpha-enolase, 2-phospho-D-glycerate hydro-lyase, C-myc promoter-binding protein, Enolase 1, MBP-1, MPB-1, Non-neural enolase, NNE, Phosphopyruvate hydratase, PPH, Plasminogen-binding protein, ENO1L1, MBPB1, MPB1, ENO1-IT1, ENO1 intronic transcript 1
Similar products	ENO1, MBP1, EC 4.2.1.11, NNE, ENO1L1, MBP-1, MPB1, PPH, MYC promoter-binding protein 1, Non-Neuronal Enolase, Enolase-1, Alpha enolase, Enolase 1, MBP 1, MBPB1, MPB-1, Phosphopyruvate hydratase, Tau-crystallin, C myc promoter binding protein, Plasminogen binding protein, 2 phospho D glycerate hydro lyase, Enolase 1 (alpha), Enolase 1 (alpha) like 1, MPB 1, MYC promoter binding protein 1, Tau crystallin, Non-Neuronal Enolase (NNE), Non Neuronal Enolase, MBPB-1, MBPB 1, Enolase1, EC4.2.1.11, ATGP0404-10ug, ATGP0404-20ug, ATGP0404-50ug, ATGP0404-100ug, ATGP0404-250ug, ATGP0404-500ug, ATGP0404-1mg, ATGP0404-010, ATGP0404-020, ATGP0404-050, ATGP0404-100, ATGP0404-250, ATGP0404-500, ATGP0404-01M
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Enzyme Activity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	47.1 kDa (434aa) confirmed by MALDI-TOF
Description	Alpha-enolase, also known as Enolase 1, is one of three enolase isoenzymes and a glycolytic enzyme expressed in most tissues. This protein plays a key role in anaerobic metabolism under hypoxic conditions and may act as a cell surface plasminogen receptor during tissue invasion. Abnormal expression of alpha-enolase is associated with tumor progression in some cases of breast and lung cancer. It also has been identified as an autoantigen associated with Hashimoto's encephalopathy and severe asthma. Recombinant human alpha-enolase was expressed in E. coli and purified by using conventional chromatography.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 7.5) containing 1mM MgSO4, 10% glycerol
Antigen Species	Human
Gene Category	Metabolism
Domain	1-434aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Specific activity is > 20, 000pmol/min/ug, and was obtained by measuring the decrease of NAD in absorbance at 340nm resulting from NADH at pH 6.5 at 37C.
Species of Protein	Human
Manufacturer - Search Terms	Tau-crystallin, Tau crystallin, PPH, Plasminogen binding protein, Phosphopyruvate hydratase, Non-Neuronal Enolase (NNE), Non-Neuronal Enolase, Non Neuronal Enolase, NNE, MYC promoter-binding protein 1, MYC promoter binding protein 1, MPB-1, MPB1, MPB 1, MBPB-1, MBPB1, MBPB 1, MBP-1, MBP1, MBP 1, Enolase-1, Enolase1, Enolase 1 (alpha) like 1, Enolase 1 (alpha), Enolase 1, ENO1L1, ENO1, EC4.2.1.11, EC 4.2.1.11, C myc promoter binding protein, Alpha enolase, 2 phospho D glycerate hydro lyase, ATGP0404-10ug, ATGP0404-20ug, ATGP0404-50ug, ATGP0404-100ug, ATGP0404-250ug, ATGP0404-500ug, ATGP0404-1mg, ATGP0404-010, ATGP0404-020, ATGP0404-050, ATGP0404-100, ATGP0404-250, ATGP0404-500, ATGP0404-01M

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/31/2025

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