Comparison

Recombinant human Thymidylate synthase/TYMS protein

Item no. NKM-ATGP0446-500ug
Manufacturer NKMAX
Amount 500 ug
Quantity options 100 ug 20 ug 500 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ FYVVNSELSC
Citations Chiu TH., et al. (2009) Anticancer Res. 29(11):4503-11.
Pena MM., et al. (2009) J Biol Chem. 284(46):31597-607.
NCBI NP_001062
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias HST422,TMS,TS,d TMP synthase,EC 2.1.1.45,MGC88736,Thymidylate synthase,Thymidylate synthetase,Tsase,TYMS,TYMS protein,Tyms thymidylate synthetase
Similar products TMS, TYMS, Thymidylate synthase, TS, HST422, MGC88736, d TMP synthase, EC 2.1.1.45, TYMS protein, Tyms thymidylate synthetase, Thymidylate synthetase, Tsase, ATGP0446-10ug, ATGP0446-20ug, ATGP0446-50ug, ATGP0446-100ug, ATGP0446-250ug, ATGP0446-500ug, ATGP0446-1mg, ATGP0446-10, ATGP0446-20, ATGP0446-50, ATGP0446-100, ATGP0446-250, ATGP0446-500, ATGP0446-1
Available
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
37.8 kDa (333aa) confirmed by MALDI-TOF
Description
Thymidylate synthase is an intracellular enzyme critical for de novo synthesis of DNA. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. In cancer, expression of this protein is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-Fu). Resistance or lack of response to 5-Fu is attributed to the elevation of thymidylate synthase activity. Recombinant human Thymidylate synthase protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.
Antigen Species
Human
Gene Category
Enzymes & Proteases
Domain
1-313aa
Species of Protein
Human
Manufacturer - Search Terms
Thymidylate synthase, HST422, TMS, TS, d TMP synthase, EC 2.1.1.45, MGC88736, Thymidylate synthase, Thymidylate synthetase, Tsase, TYMS, TYMS protein, Tyms thymidylate synthetase, ATGP0446-10ug, ATGP0446-20ug, ATGP0446-50ug, ATGP0446-100ug, ATGP0446-250ug, ATGP0446-500ug, ATGP0446-1mg, ATGP0446-10, ATGP0446-20, ATGP0446-50, ATGP0446-100, ATGP0446-250, ATGP0446-500, ATGP0446-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 ug
Available: In stock
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