Recombinant human Purine nucleoside phosphorylase/PNP protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2'-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases. Recombinant human PNP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 2mM DTT, 10% glycerol

Neuroscience

Specific activity is > 120unit/mg, and is defined as the amount of enzyme that phosphorolysis of 1.0 umole of inosine with inorganic phosphate per minute at pH 7.5 at 25C.

Purine nucleoside phosphorylase, PNP, ATGP0786-10ug, ATGP0786-20ug, ATGP0786-50ug, ATGP0786-100ug, ATGP0786-250ug, ATGP0786-500ug, ATGP0786-1mg, ATGP0786-10, ATGP0786-20, ATGP0786-50, ATGP0786-100, ATGP0786-250, ATGP0786-500, ATGP0786-1