Comparison

Recombinant human APP/Protease Nexin II protein

Item no. NKM-ATGP1499-20ug
Manufacturer NKMAX
Amount 20 ug
Quantity options 100 ug 20 ug 500 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag HIS
Purity > 85% by SDS-PAGE
Sequence <MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGS>LEVP TDGNAGLLAE PQIAMFCGRL NMHMNVQNGK WDSDPSGTKT CIDTKEGILQ YCQEVYPELQ ITNVVEANQP VTIQNWCKRG RKQCKTHPHF VIPYRCLVGE FVSDALLVPD KCKFLHQERM DVCETHLHWH TVAKETCSEK STNLHDYGML LPCGIDKFRG VEFVCCPLAE ESDNVDSADA EEDDSDVWWG
Citations Kontush A., et al. (2001) Cell. Mol. Neurobiol. 21:299-315
Walter M.F., et al. (2006) Biochem. Biophys. Res. Commun. 233:760-764
NCBI NP_000475.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Amyloid beta A4 protein,AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,CTFgamma
Similar products APP, Protease Nexin II, ATGP1499-10ug, ATGP1499-20ug, ATGP1499-50ug, ATGP1499-100ug, ATGP1499-250ug, ATGP1499-500ug, ATGP1499-1mg, ATGP1499-10, ATGP1499-20, ATGP1499-50, ATGP1499-100, ATGP1499-250, ATGP1499-500, ATGP1499-1
Available
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
34.7 kDa (308aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Description
APP, also known as amyloid beta A4 protein, functions as a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Recombinant human APP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Concentration
1mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Antigen Species
Human
Gene Category
Neuroscience
Domain
18-289aa
Species of Protein
Human
Manufacturer - Search Terms
APP, Protease Nexin II, ATGP1499-10ug, ATGP1499-20ug, ATGP1499-50ug, ATGP1499-100ug, ATGP1499-250ug, ATGP1499-500ug, ATGP1499-1mg, ATGP1499-10, ATGP1499-20, ATGP1499-50, ATGP1499-100, ATGP1499-250, ATGP1499-500, ATGP1499-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
available

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