Comparison

Recombinant human SIAH1 protein

Item no. NKM-ATGP1669-10ug
Manufacturer NKMAX
Amount 10 ug
Quantity options 10 ug 250 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Conjugate/Tag HIS
Purity > 95% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MGSVANSVLF PCKYASSGCE ITLPHTEKAD HEELCEFRPY SCPCPGASCK WQGSLDAVMP HLMHQHKSIT TLQGEDIVFL ATDINLPGAV DWVMMQSCFG FHFMLVLEKQ EKYDGHQQFF AIVQLIGTRK QAENFAYRLE LNGHRRRLTW EATPRSIHEG IATAIMNSDC LVFDTSIAQL FAENGNLGIN VTISMC
Citations Hu G., et al. (1999) Mol Cell Biol. 19: 724-732
Matsuzawas S., et al. (1998) EMBO J. 17: 2736-2747.
NCBI NP_003022
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias E3 ubiquitin-protein ligase SIAH1,SIAH1A
Similar products SIAH1, E3 ubiquitin-protein ligase SIAH1, SIAH1A, ATGP1669-10ug, ATGP1669-20ug, ATGP1669-50ug, ATGP1669-100ug, ATGP1669-250ug, ATGP1669-500ug, ATGP1669-1mg, ATGP1669-10, ATGP1669-20, ATGP1669-50, ATGP1669-100, ATGP1669-250, ATGP1669-500, ATGP1669-1
Available
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
24.1 kDa (216aa) confirmed by MALDI-TOF
Description
E3 ubiquitin-protein ligase SIAH1, also known as SIAH1, is a member of the seven in absentia homolog (SIAH) family. SIAH1 is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. SIAH1 contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. SIAH1 is known to cause indirect degradation of beta-catenin through formation of a complex with Siah-interacting protein (SIP), Skp1 and Ebi. Recombinant human SIAH1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.25mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 40% glycerol, 1mM DTT
Antigen Species
Human
Gene Category
Ubiquitination
Domain
90-282aa
Species of Protein
Human
Manufacturer - Search Terms
SIAH1, E3 ubiquitin-protein ligase SIAH1, SIAH1A, ATGP1669-10ug, ATGP1669-20ug, ATGP1669-50ug, ATGP1669-100ug, ATGP1669-250ug, ATGP1669-500ug, ATGP1669-1mg, ATGP1669-10, ATGP1669-20, ATGP1669-50, ATGP1669-100, ATGP1669-250, ATGP1669-500, ATGP1669-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close