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Recombinant human HSP60 protein

Recombinant human HSP60 protein

Item no.	NKM-ATGP2027-10ug
Manufacturer	NKMAX
Amount	10 ug
Quantity options	10 ug 250 ug 50 ug
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Targets for Rodent Neurosciences Peptides & Proteins Recombinant Proteins SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 90% by SDS-PAGE
Sequence	<MGSSHHHHHH SSGLVPRGSH MGSHM>AKDVK FGADARALML QGVDLLADAV AVTMGPKGRT VIIEQSWGSP KVTKDGVTVA KSIDLKDKYK NIGAKLVQDV ANNTNEEAGD GTTTATVLAR SIAKEGFEKI SKGANPVEIR RGVMLAVDAV IAELKKQSKP VTTPEEIAQV ATISANGDKE IGNIISDAMK KVGRKGVITV KDGKTLNDEL EIIEGMKFDR GYISPYFINT
Citations	Cappello F, Di Stefano A, et al. (2006). Cancer. 107(10):2417-24. Vilasi S,et al. Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations. (PLoS One. 2014){https://pubmed.ncbi.nlm.nih.gov/24830947/} Ricci C, et al. Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins. (Biophys Chem. 2016){https://pubmed.ncbi.nlm.nih.gov/26259786/} Ricci C, et al. Investigation on different chemical stability of mitochondrial Hsp60 and its precursor. (Biophys Chem. 2017){https://pubmed.ncbi.nlm.nih.gov/28774748/} Kaiser F, et al. Association between circulating levels of heat-shock protein 27 and aggressive periodontitis. (Cell Stress Chaperones. 2018){https://pubmed.ncbi.nlm.nih.gov/29766408/} Marino C, et al. Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation. (ACS Chem Neurosci. 2019){https://pubmed.ncbi.nlm.nih.gov/31091411/} Vilasi S, et al. Inhibition of Aβ 1-42 Fibrillation by Chaperonins: Human Hsp60 Is a Stronger Inhibitor than Its Bacterial Homologue GroEL. ACS Chem Neurosci. 2019){https://pubmed.ncbi.nlm.nih.gov/31298838/}
NCBI	NP_955472
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	60 kDa heat shock protein mitochondrial,60 kDa heat shock protein,mitochondrial,CPN60,GROEL,HLD4,HSP-60,HSP60,HSP65,HuCHA60,SPG13
Similar products	HSP-60, HSP60, mitochondrial, HSP65, CPN60, HuCHA60, GROEL, HLD4, SPG13, 60 kDa heat shock protein, 60 kDa heat shock protein mitochondrial, ATGP2027-10ug, ATGP2027-20ug, ATGP2027-50ug, ATGP2027-100ug, ATGP2027-250ug, ATGP2027-500ug, ATGP2027-1mg, ATGP2027-10, ATGP2027-20, ATGP2027-50, ATGP2027-100, ATGP2027-250, ATGP2027-500, ATGP2027-1
Available
Manufacturer - Type	Recombinant Protein
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	60 kDa (572aa)
Description	HSP60 is a mitochondrial chaperonin that is typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In addition to its role as a heat shock protein, HSP60 functions as a chaperonin to assist in folding linear amino acid chains into their respective three-dimensional structure. Through the extensive study of groEL, HSP60's bacterial homolog, HSP60 has been deemed essential in the synthesis and transportation of essential mitochondrial proteins from the cell's cytoplasm into the mitochondrial matrix. Recombinant human HSP60 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration	0.5mg/ml (determined by Bradford assay)
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol
Antigen Species	Human
Gene Category	Heat Shock Proteins
Domain	27-573aa
Species of Protein	Human
Manufacturer - Search Terms	HSP60, 60 kDa heat shock protein mitochondrial, 60 kDa heat shock protein, mitochondrial, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, ATGP2027-10ug, ATGP2027-20ug, ATGP2027-50ug, ATGP2027-100ug, ATGP2027-250ug, ATGP2027-500ug, ATGP2027-1mg, ATGP2027-10, ATGP2027-20, ATGP2027-50, ATGP2027-100, ATGP2027-250, ATGP2027-500, ATGP2027-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 7/31/2025

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