Recombinant human ASPSCR1 protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

ASPSCR1 contains a uBX domain and interacts with glucose transporter type 4 (GLuT4). This protein is a tether, which sequesters the GLuT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLuT4 to the plasma membrane within minutes of insulin stimulation. Translocation t (X; 17) (p11; q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Recombinant human ASPSCR1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Signal Transduction

Human