Recombinant human Carnosine Dipeptidase 1/CNDP1 protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

CNDP1, also known as beta-Ala-His dipeptidase, belongs to the peptidase M20A family. The shortest allelic form (CNDP1 Mannheim) was more common in the absence of nephropathy and was associated with lower serum carnosinase levels. Carnosine inhibited the increased production of fibronectin and collagen type VI in podocytes and the increased production of TGF-beta in mesangial cells. Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells. Recombinant human CNDP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

< 1 EU per 1ug of protein (determined by LAL method)

Beta-Ala-His dipeptidase, Carnosine dipeptidase 1, Carnosine Dipeptidase1, CN1, CNDP dipeptidase 1, CNDP1, CPGL2, Glutamate carboxypeptidase-like protein 2, HST2308, ATGP3227-10ug, ATGP3227-20ug, ATGP3227-50ug, ATGP3227-100ug, ATGP3227-250ug, ATGP3227-500ug, ATGP3227-1mg, ATGP3227-010, ATGP3227-020, ATGP3227-050, ATGP3227-100, ATGP3227-250, ATGP3227-500, ATGP3227-01M