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Recombinant rat Lactate Dehydrogenase A/LDHA protein

Recombinant rat Lactate Dehydrogenase A/LDHA protein

Item no.	NKM-ATGP3368-10ug
Manufacturer	NKMAX
Amount	10 ug
Quantity options	10 ug 50 ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Toxicity & Cytotoxicity
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Rat (Rattus norvegicus)
Host	Baculovirus-Infected Insect Cells
Conjugate/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	MAALKDQLIV NLLKEEQVPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG EMMDLQHGSL FLKTPKIVSS KDYSVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI IPNVVKYSPQ CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV HPLSCHGWVL GEHGDSSVPV WSGVNVAGVS LKSLNPQLGT DADKEQWKDV HK
Citations	Ward RA., et al. (2012) J Med Chem. 55:3285-3306. Fantin VR., et al. (2006) Cancer Cell. 9:425-434.
NCBI	NP_058721
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	LDH muscle subunit,LDH-M
Similar products	LDHA, Ldha, L-lactate dehydrogenase A chain, Lactate Dehydrogenase A, Ldh1, ATGP3368-10ug, ATGP3368-20ug, ATGP3368-50ug, ATGP3368-100ug, ATGP3368-250ug, ATGP3368-500ug, ATGP3368-1mg, ATGP3368-10, ATGP3368-20, ATGP3368-50, ATGP3368-100, ATGP3368-250, ATGP3368-500, ATGP3368-1
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Enzyme Activity
Manufacturer - Host	Baculovirus
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	37.5 kDa (340aa)
Description	Ldha, also known as lactate dehydrogenase A, catalyzes the conversion of pyruvate to lactate, utilizing NADH as a cofactor. It has been identified as a potential therapeutic target in the area of cancer metabolism. Reduction in Ldha activity resulted in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential. Recombinant rat Ldha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration	0.25mg/ml (determined by absorbance at 280nm)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 1mM DTT, 20% glycerol
Antigen Species	Rat
Gene Category	Signal Transduction
Domain	1-332aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Specific activity is > 200unit/mg, in which one unit will convert 1.0 umole of pyruvate to L-lactate and beta-NAD per minute at pH 7.5 at 37C.
Predicted nterm	Met1
Species of Protein	Rat
Manufacturer - Search Terms	Lactate Dehydrogenase A, LDHA, L-lactate dehydrogenase A chain, Ldha, Ldh1, ATGP3368-10ug, ATGP3368-20ug, ATGP3368-50ug, ATGP3368-100ug, ATGP3368-250ug, ATGP3368-500ug, ATGP3368-1mg, ATGP3368-10, ATGP3368-20, ATGP3368-50, ATGP3368-100, ATGP3368-250, ATGP3368-500, ATGP3368-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 9/4/2025

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