Recombinant human SHP-2/PTPN11 protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

PTPN11, also known as tyrosine-protein phosphatase non-receptor type 11 isoform 2, belongs to the protein-tyrosine phosphatase (PTP) family, non-receptor class 2 subfamily. It participates in signal transduction from the cell surface to the nucleus downstream of various receptor and cytosolic protein tyrosine kinases. This protein deficient cells have poor mobility because excessive phosphorylation of FAK and other proteins interferes with the rotation of cell attachment points in the focal adhesion complex. Recombinant human PTPN11, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

< 1 EU per 1ug of protein (determined by LAL method)

Human

PTPN11, Tyrosine-protein phosphatase non-receptor type 11 isoform 2, PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, ATGP3714-10ug, ATGP3714-20ug, ATGP3714-50ug, ATGP3714-100ug, ATGP3714-250ug, ATGP3714-500ug, ATGP3714-1mg, ATGP3714-10, ATGP3714-20, ATGP3714-50, ATGP3714-100, ATGP3714-250, ATGP3714-500, ATGP3714-1