Recombinant human Neuropilin 1/NRP1 protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

NRP1, also known as neuropilin-1 isoform a, is a type 1 transmembrane protein. This protein is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor and semaphorin family members. It is a VEGF165 and semaphorin receptor expressed by vascular endothelial cells (EC) and tumor cells. It is a co-receptor for VEGF receptor (VEGFR2) that enhances the binding of VEGF 165 to VEGFR2 and VEGF165-mediated chemotaxis. Also, it plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. Recombinant human NRP1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Angiogenesis

< 1 EU per 1ug of protein (determined by LAL method)

Human