Recombinant human SIRP beta 1/CD172b protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

SIRPB1, also known as signal-regulatory protein beta-1 isoform 1, is a type I transmembrane protein of SIRP superfamily. It is an immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein also participates in the recruitment of tyrosine kinase SYK. And it acts as an activating isoform of SIRP alpha molecules that recruit SHP-1 and SHP-2 protein tyrosine phosphatases and activate counterparts, whose engagement couples to protein tyrosine kinases. Recombinant human SIRPB1 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Signal Transduction

< 1 EU per 1ug of protein (determined by LAL method)

Human