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Recombinant human IL-15 protein

Recombinant human IL-15 protein

Item no.	NKM-ATGP3844-10ug
Manufacturer	NKMAX
Amount	10 ug
Quantity options	100 ug 10 ug 20 ug 250 ug 500 ug 50 ug 5 ug
Category	Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines SDS-PAGE
Type	Proteins Recombinant
Format	Liquid
Applications	SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	HIS
Purity	> 95% by SDS-PAGE
Sequence	MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECEELEEKNIKEF LQSFVHIVQM FINTS<LEHHH HHH>
Citations	J G Giri., et al. (1994) EMBO. 13(12): 2822-2830. Lorenzen I., et al. (2006). J Biol Chem. 281(10):6642-7 Kim HR, et al. Anti-cancer activity and mechanistic features of a NK cell activating molecule. (Cancer Immunol Immunother. 2009){https://pubmed.ncbi.nlm.nih.gov/19259669/} Yoon JC, et al. Cell-to-cell contact with hepatitis C virus-infected cells reduces functional capacity of natural killer cells. (J Virol. 2011){https://pubmed.ncbi.nlm.nih.gov/21937646/}
NCBI	NP_751914.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Interleukin-15
Similar products	IL15, IL-15, Interleukin-15, Interleukin 15, IL 15, Interleukin15, ATGP3844-10ug, ATGP3844-20ug, ATGP3844-50ug, ATGP3844-100ug, ATGP3844-250ug, ATGP3844-500ug, ATGP3844-1mg, ATGP3844-010, ATGP3844-020, ATGP3844-050, ATGP3844-100, ATGP3844-250, ATGP3844-500, ATGP3844-01M, ILO0701
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Applications	SDS-PAGE, Bioactivity
Storage Conditions	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight	13.9 kDa (123aa) confirmed by MALDI-TOF
Description	Interleukin (IL) -15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15R alpha) from one subset of cells presents IL-15 to neighboring IL-2R beta/gamma (c) -expressing cells. This newly discovered cytokine is produced by a wide variety of cells and tissues and like IL-2, stimulates the proliferation of T-lymphocytes and induces the generation of cytotoxic T-lymphocytes (CTLs) and lymphokine-activated killer (LAK) cells. Recombinant human IL-15 was expressed in E. coli and purified by using conventional chromatography after refolding of the isolated inclusion bodies in a redox buffer.
Concentration	1mg/ml (determined by Bradford assay)
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species	Human
Gene Category	Hormones & Cytokines
Domain	49-162 aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only	Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 range ≤1ng/ml.
Species of Protein	Human
Manufacturer - Search Terms	IL15, IL 15, IL-15, Interleukin 15, Interleukin15, Interleukin-15, ATGP3844-10ug, ATGP3844-20ug, ATGP3844-50ug, ATGP3844-100ug, ATGP3844-250ug, ATGP3844-500ug, ATGP3844-1mg, ATGP3844-010, ATGP3844-020, ATGP3844-050, ATGP3844-100, ATGP3844-250, ATGP3844-500, ATGP3844-01M, ILO0701

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 7/31/2025

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