Comparison

Recombinant human Neprilysin/CD10 protein

Item no. NKM-ATGP3907-250ug
Manufacturer NKMAX
Amount 250 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host Baculovirus-Infected Insect Cells
Conjugate/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <ADP>YDDGICK SSDCIKSAAR LIQNMDATTE PCTDFFKYAC GGWLKRNVIPETSSRYGNFDILRDELEVVL KDVLQEPKTE DIVAVQKAKA LYRSCINESA IDSRGGEPLLKLLPDIYGWPVATENWEQKY GASWTAEKAI AQLNSKYGKK VLINLFVGTD DKNSVNHVIHIDQPRLGLPSRDYYECTGIY KEACTAYVDF MISVARLIRQ EERLPIDENQ LALEMNKVMELEKEIAN
Citations Auer-Grumbach M., et al. (2016) Am J Hum Genet. 99:607-623.
Hama E., et al. (2005) Med Hypotheses. 65:498-500.
NCBI NP_000893
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias MME,Neprilysin,CALLA,CD10,CMT2T,NEP,SCA43,SFE,Atriopeptidase,Common acute lymphocyticleukemia antigen,Enkephalinase,Neutral endopeptidase,Skin fibroblast elastase,Membrane metalloendopeptidase,EPN
Similar products Neprilysin, ATGP3907-10ug, ATGP3907-20ug, ATGP3907-50ug, ATGP3907-100ug, ATGP3907-250ug, ATGP3907-500ug, ATGP3907-1mg, ATGP3907-10, ATGP3907-20, ATGP3907-50, ATGP3907-100, ATGP3907-250, ATGP3907-500, ATGP3907-1
Available
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Enzyme Activity
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
80.9 kDa (708aa)
Description
Neprilysin, also known as MME, is a zinc metallopeptidase expressed at the cell surface of a variety of cells. It degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. It is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). It is of use in hematological diagnosis since it is expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. Recombinant human neprilysin, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
1mg/ml (determined by absorbance at 280nm)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 0.1mM PMSF, 10% glycerol
Antigen Species
Human
Gene Category
Immunology
Domain
52-750aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Specific activity is > 5, 000pmol/min/ug in which one unit will convert 1.0pmole of Mca-SEVNLDAEFRK(Dnp)RR-NH2 to MCA- Pro-Leu-OH per minute at pH 8.8 at 25C.
Predicted nterm
Ala
Species of Protein
Human
Manufacturer - Search Terms
Neprilysin, ATGP3907-10ug, ATGP3907-20ug, ATGP3907-50ug, ATGP3907-100ug, ATGP3907-250ug, ATGP3907-500ug, ATGP3907-1mg, ATGP3907-10, ATGP3907-20, ATGP3907-50, ATGP3907-100, ATGP3907-250, ATGP3907-500, ATGP3907-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 250 ug
Available: In stock
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