Comparison

Recombinant human IL-10 protein

Item no. NKM-ATGP3920-100ug
Manufacturer NKMAX
Amount 100 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against Human (Homo sapiens)
Host Baculovirus-Infected Insect Cells
Conjugate/Tag HIS
Purity > 95% by SDS-PAGE
Sequence SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN <HHHHHH>
Citations Jog NR., et al. (2018) Front Immunol. 9:2198.
Harling K., et al. (2019) Cell Mol Immunol. 16:275-287.
Lee HM, et al. A comparative study of the effects of inhibitory cytokines on human natural killer cells and the mechanistic features of transforming growth factor-beta. (Cell Immunol. 2014){https://pubmed.ncbi.nlm.nih.gov/24879062/}
NCBI NP_000563
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Interleukin-10,IL-10,Cytokine synthesis inhibitory factor,CSIF,GVHDS,IL10A,TGIF,T-cell growth inhibitory factor
Similar products IL-10, IL10, Interleukin-10, Cytokine synthesis inhibitory factor, TGIF, Interleukin 10, IL 10, CSIF, IL10A, GVHDS, Interleukin10, T-cell growth inhibitory factor, ATGP3920-10ug, ATGP3920-20ug, ATGP3920-50ug, ATGP3920-100ug, ATGP3920-250ug, ATGP3920-500ug, ATGP3920-1mg, ATGP3920-010, ATGP3920-020, ATGP3920-050, ATGP3920-100, ATGP3920-250, ATGP3920-500, ATGP3920-01M
Available
Manufacturer - Type
Recombinant Protein
Manufacturer - Applications
SDS-PAGE, Bioactivity
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
19.4 kDa (166aa)
Description
IL-10, also known as Interleukin-10, is an anti-inflammatory cytokine. It inhibits the synthesis of pro-inflammatory cytokines like IFN-gamma, IL2, IL3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. This protein has effects in immunoregulation and inflammation and down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This protein controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. Recombinant human IL-10, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
Human
Gene Category
Hormones & Cytokines
Domain
19-178aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment Only
Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 range ≤5ng/ml.
Predicted nterm
Ser19
Species of Protein
Human
Manufacturer - Search Terms
Interleukin10, Interleukin 10, Interleukin-10, IL-10, IL10, IL 10, Cytokine synthesis inhibitory factor, CSIF, GVHDS, IL10A, TGIF, T-cell growth inhibitory factor, ATGP3920-10ug, ATGP3920-20ug, ATGP3920-50ug, ATGP3920-100ug, ATGP3920-250ug, ATGP3920-500ug, ATGP3920-1mg, ATGP3920-010, ATGP3920-020, ATGP3920-050, ATGP3920-100, ATGP3920-250, ATGP3920-500, ATGP3920-01M

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

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