Recombinant human PON1 protein

Recombinant Protein

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

PON1, also known as A esterase1, is a member of the paraoxonase family. It is an enzyme that hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. It is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). This protein is activated by PPAR-gamma, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis. PON1 shows a variety of atheroprotective properties by metabolizing inflammatory lipid peroxides. It has evolved to be a highly promiscuous enzyme capable of hydrolysing a wide variety of substrates such as lactones, cyclic carbonates, organophosphorus pesticides and nerve gases. Recombinant human PON1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Neuroscience

< 1 EU per 1ug of protein (determined by LAL method)

Leu 16

, ATGP3936-10ug, ATGP3936-20ug, ATGP3936-50ug, ATGP3936-100ug, ATGP3936-250ug, ATGP3936-500ug, ATGP3936-1mg, ATGP3936-10, ATGP3936-20, ATGP3936-50, ATGP3936-100, ATGP3936-250, ATGP3936-500, ATGP3936-1