Comparison

Recombinant MERS-CoV Spike protein

Item no. NKM-ATGP3979-10ug
Manufacturer NKMAX
Amount 10 ug
Quantity options 100 ug 10 ug 20 ug 250 ug 500 ug 50 ug
Category
Type Proteins Recombinant
Format Liquid
Applications SDS-PAGE
Specific against MERS-CoV
Host Baculovirus-Infected Insect Cells
Conjugate/Tag HIS
Purity > 85% by SDS - PAGE
Sequence YVDVGPDSVK SACIEVDIQQ TFFDKTWPRP IDVSKADGII YPQGRTYSNI TITYQGLFPY QGDHGDMYVY SAGHATGTTP QKLFVANYSQ DVKQFANGFV VRIGAAANST GTVIISPSTS ATIRKIYPAF MLGSSVGNFS DGKMGRFFNH TLVLLPDGCG TLLRAFYCIL EPRSGNHCPA GNSYTSFATY HTPATDCSDG NYNRNASLNS FKEYFNLRNC TFMYTYNITE DE
Citations Junghyun Goo., et al. (2020) Virus Res. 278:197863.
Yan-Hua Li., et al. (2019) Engineering. 5:940-947.
Lingshu Wang., et al. (2018) J Virol. 92:e02002-2017.
Nicolas Papageorgiou., et al. (2016) Acta Crystallogr D Struct Biol. 72:192-202.
Xiao-Yan Che., et al. (2004) J Clin Microbiol. 42:2629-2635.

Goo J, et al. Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein. (Virus Res. 2020){https://pubmed.ncbi.nlm.nih.gov/31945421/}
NCBI AFS88936
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Middle East respiratory syndrome coronavirus,Human betacoronavirus 2c EMC/2012,MERS-CoV,MERS,MERS-CoV SP,Spike glycoprotein,S glycoprotein,S,Spike protein
Similar products sars, covid-19, covid19, sars2, ATGP3979-10ug, ATGP3979-20ug, ATGP3979-50ug, ATGP3979-100ug, ATGP3979-250ug, ATGP3979-500ug, ATGP3979-1mg, ATGP3979-10, ATGP3979-20, ATGP3979-50, ATGP3979-100, ATGP3979-250, ATGP3979-500, ATGP3979-1
Available
Manufacturer - Type
Recombinant Protein
Manufacturer - Host
Baculovirus
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
141.6kDa(1285aa)
Description
MERS-CoV, which causes the Middles East Respiratory Syndrome (MERS), belongs to a family of viruses known as coronaviruses. MERS-CoV was first identified in the Kingdom of Saudi Arabia in 2012, which is a single and positive stranded RNA virus. Dromedary camels are widely considered as the source of the transmission of MERS-CoV. The rate of human transmission among household contacts of MERS patients has been approximately 5 % based on serological analysis. MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid) proteins. The spike protein, responsible for allowing the virus to attach to and fuse with the membrane of a host cell and is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. MERS-CoV S mediates viral attachment and fusion to human cells via human cellular receptor DPP4, also known as CD26. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. Recombinant MERS-CoV Spike, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Concentration
0.25mg/ml (determined by Bradford assay)
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Antigen Species
MERS-CoV
Gene Category
Virus
Domain
18-1296aa
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Predicted nterm
Tyr 18
Species of Protein
MERS-CoV
Manufacturer - Search Terms
covid-19, covid19, sars, sars2, ATGP3979-10ug, ATGP3979-20ug, ATGP3979-50ug, ATGP3979-100ug, ATGP3979-250ug, ATGP3979-500ug, ATGP3979-1mg, ATGP3979-10, ATGP3979-20, ATGP3979-50, ATGP3979-100, ATGP3979-250, ATGP3979-500, ATGP3979-1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
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